Themis R. Kyriakides

Cellular and molecular events at the interface between implanted biomaterials and tissues; biomaterial-induced inflammation, wound healing, tissue regeneration with a focus on angiogenesis, and extracellular matrix remodeling; in vivo work on genetically-modified mice; gene delivery from biomaterials; development of biodegradable polymers; modification of glucose sensors; development of artificial skin.

 

REPRESENTATIVE PUBLICATIONS

• Tian W., Kyriakides T.R. Thrombospondin 2-null mice display an altered brain foreign body response to polyvinyl alcohol sponge implants. Biomedical Materials 4 (1): 015009, 2009.
• MacLauchlan S., Skokos E., Meznarich N., Zhu D., Raoof S., Shipley J.M., Senior R.M., Bornstein P., Kyriakides T.R.. Abnormal foreign body response in mice that lack matrix metalloproteinase-9 associated with disordered matrix remodeling, compromised angiogenesis, and foreign body giant cell formation. J. Leukocyte Biology (in press) 2009.
• W. Tian, T.R. Kyriakides. Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL1-b levels and leakage of the blood brain barrier. Matrix Biology (accepted, 2009).
• Lin S.-P., Kyriakides TR, Chen J.-J. Characterization of a three-dimensional matrix on microelectrode arrays for on-line cell growth observation. Biomaterials (accepted, 2009).
• Jay, S.M., Skokos, E., Zeng, J., Knox, K., Kyriakides, T.R. Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in in vitro and in vivo in mouse models. J. Biomed. Mat. Res. Part A (in press 2009).
• Krady M.M., Zeng J., Yu J., MacLauchlan S, Skokos E.A., Bornstein P., Sessa W.C., Kyriakides T.R. Thrombospondin-2 modulates extracellular matrix remodeling during physiologic angiogenesis. American Journal of Pathology 173:879-91. 2008.
• Cahn F., Kyriakides T.R. Generation of an artificial skin construct containing a non-degradable fiber mesh: a potential transcutaneous interface. Biomedical Materials 3:034110. 2008.
• Jay, S.M., Skokos, E., Laiwalla, F., Krady, M.M., Kyriakides, T.R. Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. American Journal of Pathology, 171: 2, 2007.
• The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation , Themis R Kyriakides, M.J. Foster, G.E. Keeney, A. Tsai, C.M. Giachelli, B.J. Rollins, P. Bornstein, 2004, Am. J. Pathol..
• pH-sensitive polymers that enhance intracellular drug delivery in vivo , Themis R Kyriakides, C.C. Cheung, N. Murthy, P. Bornstein, P.S. Stayton, A.S. Hoffman, 2001, J. Contr. Rel., 78, 295-303.
• Modulation of angiogenesis and matrix remodeling by localized, matrix-mediated, antisense gene delivery, Themis R Kyriakides, T. Hartzel, G. Huyen, P. Bornstein, 2001, Mol. Ther., 3, 842-849.
• Mice that lack the angiogenesis inhibitor thrombospondin 2 mount an altered foreign body reaction characterized by increased vascularity, Themis R Kyriakides, K. J. Leach, A.S. Hoffman, B.D. Ratner, P. Bornstein , 1999, Proc.Natl. Acad. Sci. (USA), 13, 4449-4454.